Sathyaraj, Aishwarya Rajesh and Darshan in the lead roles of Kanaa movie. All rights reserved.Kanaa is a 2018 drama Tamil movie is based on sports. Its safety profile was comparable to heparin lock solution.Ĭathasept EDTA Hemodialysis antimicrobial bacteremia bacteria catheter lock catheter-related bloodstream infection (CRBSI) central venous catheters colonization end-stage renal disease (ESRD) heparin inflammation patency yeast.Ĭopyright © 2015 National Kidney Foundation, Inc. Study was underpowered to assess effect on CRBSI, terminated early due to slow recruitment, and not double blinded.Ĭathasept significantly reduced tunneled hemodialysis catheter colonization, but the reduction in CRBSIs was not statistically significant, and it was associated with more thrombotic complications. Anemia marker levels were similar in both groups. Mean high-sensitivity C-reactive protein level was 11.6±5.3 (SE) mg/L lower for patients in the heparin group (P=0.03). The proportion of dialysis sessions with achieved prescribed blood flow rate was significantly lower in the Cathasept group (66.8% vs 75.3% P<0.001), with more patients requiring thrombolytic locks or infusions to maintain catheter patency (22 vs 9 P=0.01). CRBSI rates were 0.28/1,000 catheter-days in the Cathasept group and 0.68/1,000 catheter days in the heparin group (IRR, 0.40 95% CI, 0.08-2.09 P=0.3). Incidence rates of catheter colonization were 0.14/1,000 catheter-days in the Cathasept group and 1.08/1,000 catheter-days in the heparin group (incidence rate ratio, 0.13 95% CI, 0.003-0.94 P=0.02). Weekly through-catheter quantitative blood culture, high-sensitivity C-reactive protein fortnightly, and full blood count and ferritin monthly. Secondary outcomes included CRBSI rate, catheter patency, and biomarkers of inflammation and anemia. Primary outcome was clinically significant microbial colonization of the catheter, defined as a through-catheter quantitative blood culture yielding ≥ 1,000 colony-forming units/mL of bacteria or yeast. Patients were randomly assigned to receive Cathasept 4% locks (Cathasept group) or stayed with heparin 5,000 U/mL locks (heparin group), filled thrice weekly according to catheter lumen volume until the catheter was removed or for a maximum of 8 months. Multicenter prospective randomized controlled study.ġ17 maintenance HD patients with confirmed uncolonized tunneled HD catheters from 4 HD centers. Cathasept (tetra-sodium EDTA) solution has antimicrobial and anticoagulant activities. Catheter-related bloodstream infections (CRBSIs) cause morbidity and mortality in hemodialysis (HD) patients.
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